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A 2024 metabolism study added another layer of complexity

Vitamin B12 is a key component of several metabolic pathways in the brain

Conditions affecting any stage of this absorption pathwayincluding pernicious anaemia (an autoimmune condition destroying intrinsic factor-producing cells), Crohn's disease, coeliac disease, or surgical removal of stomach or ileal tissuecan significantly impair B12 absorption despite its water-soluble properties

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