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Ben-Sahra et al., 2016

doi: 10.1186/1471-2458-10-595 95

both increase ROS accumulation in key regions like the gut and brain, contributing to cellular senescence, neuroinflammation, and cognitive dysfunction (Wang et al., 2010

Biochemically, LCD proceeds upon LMP when cells are exposed to various lysosomotropic detergents (e.g., lipid metabolites (phosphatidic acid, sphingosine), ROS), including cathepsins [178,179,180,181] (Fig