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When copper metabolism is disrupted, either through excess copper or copper deficiency, it can trigger abnormal immune responses, thereby exacerbating neuronal damage, especially in neurodegenerative diseases such as ischemic stroke (200)

The improved method utilizes the chromogenic Fe3+-xylenol orange reaction, in which a purple complex is formed when Fe2+ provided in the reagent is oxidized to Fe3+ by peroxides present in the sample

10.1182/blood-2015-08-663245 105 WalshT

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