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Oxidative stress-induced mitochondrial fission has been implicated in RGC degeneration, with the loss of proteins such as AKAP1 leading to Drp1-mediated mitochondrial fission, increased ROS production, and diminished ATP synthesis, further contributing to RGC death (127, 128)

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BKM-120, PI3K Inhibitor, Demonstrates Acceptable Tolerability And Prelimary Activity In A Phase I/II Trial Of Patients With Advanced Leukemia's

In vitro assay of two peptides exhibited antioxidant activities when extracted from the protein hydrolysates of the skin of fishes, horse mackerel ( Magalaspiscordyla ), croaker (Otolithes ruber), and the cuttlefish ( Sepia officinalis ) by-products, like viscera and skin, gave eight hydrolysates when treated with different gastrointestinal proteases like crude alkaline enzyme, trypsin, chymotrypsin, and proteases from bacteria (87)