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Se diferencia del pptido nativo por la sustitucin Glu3Arg y una extensin N-terminal de 13 aminocidos, que le confieren baja afinidad por las IGFBP, semivida de 20-30 horas y potencia 2-3 veces mayor

12D shows microscopy images of HT-1080 cells that were transfected for 48 hours with either a control plasmid (pMaxGFP) or pCMV6-SLC7A11-DDK then treated with DMSO, erastin or SAS, as indicated, and photographed

More importantly, the risk of developing hepatocellular carcinoma from NASH has also been highlighted in recent studies