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This makes it of particular interest in studies targeting body recomposition and long-term metabolic efficiency, where muscle retention is critical for sustaining basal metabolic rate

Most of the evidence supporting this claim comes from a few observational studies

It is important to note that all current evidence derives from in vitro cellular models and in vivo animal studies, and no human clinical trials have been conducted as of February 2026

Weight Loss and Body Composition: In human clinical trials involving 300 participants, those treated with AOD 9604 showed a significant reduction in body weight compared to the placebo group