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It was showed that NP4 treatment leaded to an increase in pro-inflammatory M1-type macrophages and a decrease in anti-inflammatory M2-type macrophages in mouse tumor tissues, with the proportion of M1 to M2 macrophages being 4.4 times higher compared to untreated mouse tumor tissues (Fig

Methionine, in the form of S-adenosylmethionine (SAM), is required for many methylation reactions, including DNA methylation

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Both human and animal studies have shown that vitamin B 12 deficiency is associated with altered lipid profile and play an important role in the prediction of metabolic risk, however, as of yet, no direct mechanism has been investigated to confirm this