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Some research suggests that GLP-1 receptor activation may also directly relax the lower esophageal sphincter, making it even more susceptible to opening when it should stay shut

Metabolic Pharmaceuticals, a subsidiary of Calzada Ltd., had no choice but to terminate all further efforts and funding related to AOD-9604: In 2007, the company that owns Metabolic Pharmaceuticals, Calzada, reported to their shareholders that AOD-9604 showed no promise, and was being abandoned as a weight loss drug