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They result from a combination of factors such as decreased collagen and elastin production, loss of hydration, and cumulative damage from environmental factors like UV exposure

Le, Carolyn Chlebek, Clifford J

Zinc plays a vital role in maintaining the homeostasis of intestinal epithelial cells, and its deficiency can lead to alterations in their integrity and function

Mechanistically, the inflammation mediated by the Caspase-1/NLRP3, TLR4/NLRP3, MAPK/NF-B/NLRP3, and Nrf2/HO-1/NLRP3 pathways have been implicated in the pathogenesis and progression of AP (Papantoniou et al., 2024), highlighting their potential as therapeutic targets