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436 In NSCLC, the complementary roles of the TRX and GSH antioxidant systems are also evident, as simultaneous inhibitionvia Auranofin treatment combined with GSR (GSH pathway) losssynergistically elevates ROS levels, overwhelms cellular redox defenses, and triggers apoptosis, thereby sensitizing cancer cells to TRXR inhibition

Cells 12 (3), 493

In vivo studies using Wistar rats in which honey was ingested with Aloe vera showed that these apoptotic effects complement the cell cycle arrest described in Section 4.1 (59)