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CD38 is also one of the three ectoenzymes in the CD38/CD203a/CD73 pathway that produces ADO, which not only regulates immune response in hypoxic conditions but also suppresses the antitumor immune response by recruiting MDSCs and Treg cells, inhibiting the activity of T effector cells and thus favoring tumor progression

"Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis"

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This increases the risk of neural tube defects, such as spina bifida, developing in the unborn baby