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However, their practical use is limited by restricted access to human brain tissue, low cell yields, and the limited proliferative capacity in vitro ( Analyzing deeply the existing differences between human and rodent microglia, the first share many conserved features with their rodent counterparts, including expression of key markers such as Iba1, the transcription factor PU.1, and the adaptor protein DNAX-activating protein of 12 kDa (DAP12), along with similar responses to stimuli, including macrophage colony-stimulating factor (M-CSF) and LPS (157161)

Alfayez M, Kantarjian H, Ravandi F, Konopleva M, Jabbour E, Garcia-Manero G, Kadia T, Borthakur G, DiNardo C, Estrov Z, Pemmaraju N, Pierce S, Yilmaz M, Short N, Takahashi K, Assi R, Andreeff M , Cortes JE, Daver N

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