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Given the potential relevance of these findings, it will be essential to validate the results in patient samples and correlate them with clinical information and dietary habits

Vitamin B12 deficiency itself is not directly linked to weight gain, but it can affect metabolism and energy levels, potentially leading to weight changes

A research study to look into the long-term effect on weight loss of CagriSema in people with obesity (NCT06780449) Summary: This is an ongoing Phase 3 trial (as of current knowledge) designed to evaluate the long-term efficacy and safety of once-weekly CagriSema in people living with obesity

Because NNMT consumes nicotinamide, its inhibition theoretically increases the availability of nicotinamide for entry into the NAD + salvage pathway via nicotinamide phosphoribosyltransferase (NAMPT)