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The default settings for the SZMAP and Gameplan applications were used in all the calculations

(Beijing, China) were used for experiments

Specific NAD and glutathione forms correlate with glucose and lipid homeostasis and liver function The result that the redox metabolites follow a gaussian distribution in normal population, together with the previous knowledge that niacin supplementation can increase blood glucose and decrease cholesterol levels 28 prompted us to ask whether physiological NADs and glutathione levels correlated with glucose and lipid homeostasis, liver function tests, B vitamins and fatty acid metabolism in healthy individuals (Fig

MAFLD is defined as hepatic steatosis with metabolic dysregulation, type 2 diabetes mellitus, overweight or obesity, and is characterized by extensive liver lesions, which can progress from isolated steatosis to metabolic dysfunction-associated steatohepatitis (MASH), liver fibrosis, and even HCC