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CD4 is a co-receptor for major histocompatibility complex (MHC) class II molecules, and the primary cell surface receptor for Simian immunodeficiency virus (SIV)/Human immunodeficiency virus (HIV) (Dalgleish et al., In CD4+ T cell antigen receptor-mediated signaling, the polymorphic regions of the MHC class II proteins engage the receptor complex, whereas the non-polymorphic regions engage the CD4 co-receptor (Parnes, 1989)

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