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The figures ( Figures 1 , 2 ), created with BioRender.com, significantly enhance the clarity of our study

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654,655 Perls staining and measurements of non-hemoglobin iron revealed iron overload in the ipsilateral cortex of TBI mice and brain microvascular endothelial cells (BMECs)

Apoptosis, the quintessential programmed cell death process, primarily relies on the caspase family for initiation and is typically characterized by membrane contraction, chromatin concentration and apoptotic body formation (103)