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The commonly used non-selective NSAIDs, diclonenac (Voltaren) and ibuprofen were associated with a 50 per cent and 31 per cent increased risk respectively

Both smoking and adiposity are independent predictors of mortality, but the combination of current or recent smoking with a BMI 35 or a large waist circumference is related to an especially high mortality risk.22 Besides, smokers in general tend to have a very sedentary life since the practice of physical exercise is difficult for them

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The researchers looked at hormonal changes, insulin resistance, metabolic effects, and any signs of damage to liver and nervous tissues