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If nasal delivery achieves effective central appetite suppression at lower total systemic doses than injection, the cost per therapeutic outcome could potentially favor the nasal route despite lower bioavailability

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Currently, the analysis of biomarkers of apatinib in the treatment of GC after chemotherapy is mainly based on serum VEGFR-2 (95), serum carbohydrate antigen 19-9, carcinoembryonic antigen (CEA), tumor supplied group factor (TSGF), tumor necrosis factor- (TNF-) and inflammatory factors (105, 107)