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Second, GAMs also secrete matrix metallopeptidase 2 (MMP2) and MMP9, which are able to breakdown matrix proteins, such as collagen and fibronectin, thereby enabling glioma cells to penetrate and invade the surrounding stromal tissues (129)

To control that this basal activity is really mediated by MRP1, we mutated in MRP1 WT a cluster of 6 residues that were proven to be involved either in GSH binding or transport, R1138, R1142 38 , S1252, E1253 39 , or in binding of the GSH moiety of LTC 4 , R1249 and N1245 40

Arterioscler Thromb Vasc Biol (2005) 25:20628

Progression marker of Parkinsons disease: a 4- year multi- site imaging study