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For Crystaline silica, for both the occupational low- and high-risk scenarios, the predicted lower respiratory exposure was higher than the minimum PoD from transcriptomics, but neither scenario led to exposures which exceed the minimum PoDs for other readouts

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Specifically, they noticed a substantial decrease in the expression of lipogenic genes, including ACC , PPAR , and CPT-1a , following the administration of sodium butyrate therapy in comparison to the control treatment