ethanol metabolism depletes glutathione The Role of in Chronic Illness Development and Its Potential Use as a Novel Therapeutic Target Ethanol Metabolism: Enzymes, Steps, Reactions

Disclosures: Aiwei Zhou: Nothing to Disclose, Zhifeng Xi: Nothing to Disclose, Kang He: Nothing to Disclose, Hualian Hang: Nothing to Disclose, Hanyong Sun: Nothing to Disclose, Yongbing Qian: Nothing to Disclose, Wei Geng: Nothing to Disclose, Jie Cao: Nothing to Disclose, Lei Xia: Nothing to Disclose, Jianjun Zhang: Nothing to Disclose, Qiang Xia: Nothing to Disclose 1308 THE UTILITY OF FOLLOW-UP TRANSTHORACIC ECHOCARDIOGRAM (TTE) TO SCREEN FOR SEVERE PORTOPULMONARY HYPERTENSION (POPH) IN PATIENTS GRANTED POPH MODEL FOR END-STAGE LIVER DISEASE (MELD) EXCEPTIONS Kathryn del Valle 1 Dana Kay 2 Michael Krowka 3 James Runo 4 Corey Sadd 4 Julie Heimbach 3 Rodrigo Cartin-Ceba 5 Hector Cajigas 3 Charles Burger 6 John Moss 6 Hilary DuBrock 3 , 1 Mayo Clinic, 2 University of Cincinnati, 3 Mayo Clinic Rochester, 4 University of Wisconsin, Madison, 5 Mayo Clinic Arizona, 6 Mayo Clinic Florida Background: Current Model for End Stage Liver Disease (MELD) exception policies for patients with portopulmonary hypertension (POPH) require serial right heart catheterizations (RHC) every 3 months in order to accrue and maintain exception points

It can be taken with or without food, providing flexibility for the patient's dietary needs and preferences

Crouse, Jennifer Watts, Nicole E

Importantly, there is potential for addressing these conditions through a unified therapeutic approach, targeting the Nrf2 or NF-B signaling pathways