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The binding of Cd (II) to the dimeric R3 produces changes on its conformation demonstrated by CD (Jiang et al., 2 at 3 and 10 mg/Kg/day/412 weeks, intragastric) induced P-Tau, suggesting that As-destabilization and disruption of the cytoskeletal framework may lead to axonal degeneration (Vahidnia et al., 2008)

Melatonin ameliorates anxiety-like behaviors induced by sleep deprivation in mice: role of oxidative stress, neuroinflammation, autophagy and apoptosis