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The implication of these findings is that excess removal of hydrogen peroxide contributes to reductive stress that promotes protein misfolding and aggregation and the resulting cardiac dysfunction

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Recent studies also show heterogeneity: some report no distinct circadian rhythm in total fat during the early stages of mature milk, whereas others indicate that fat concentration increases between 10:00 a.m

It is possible that pKa of each cysteine in Vfr is different depending on its surrounding context and has a different propensity to be reduced by GSH