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(1986) showed that 10 7 10 3 M GSH or oxidized GSH (GSSG) decreased the affinity of binding sites for [ 3 H]glutamic acid (Glu) through either interacting with synaptic receptors or regulating Glu uptake by central neurons in the rat brain.Citation 19 Afterwards, GSSG but not GSH was shown to selectively attenuate intracellular calcium ([Ca 2+ ]i) and whole-cell currents induced by N-methyl-D-aspartate (NMDA) in rat cortical and retinal ganglion neuron cells