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5 Translational perspectives 5.1 Preclinical models and biomarker development The preclinical models and biomarker development represent the cornerstone of translational research towards incorporation of natural supplements in breast cancer therapy by adding mechanistic insights, validating efficacy, predicting therapeutic response, relevance towards patients for personalized therapy as well as on addressing their safety and dosing issues (219)

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More recently, the TMEM175 gene encoding a lysosomal potassium channel has emerged as a relevant PD gene in both familial and sporadic forms (Carrillo et al., 2025a