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As noted earlier, our study data may also be explained by the cerebral accumulation of APAP since it is known to readily cross the BBB 7,8

An expansion of terminal labeling laterally was also occasionally seen in PEG-fused animals (3 out of 23 cases) into the area typically innervated by sural projections from the lateral aspect of the ankle (Swett and Woolf, 1985)