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Lv et al., 2023a

Likewise, EVs from young mouse adipose tissue MSCs transporter relatively high levels of NAMPT, which induces elevated NAD + generation and affects SIRT1, ultimately enhancing cell activity and macrophage polarization from the SIRT1/PPAR/PGC-1 pathway and the SIRT1/NF-kappa B p65/NLRP3 pathway, respectively [148]

Synergistic combinations with BPC-157 and TB-500 are being investigated in research, as these peptides act on complementary signaling pathways

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