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Improves Cardiac Function: Increases cardiac output and left ventricular function independently of GH, likely through myocardial GHS-R1a activation 3

These users report appreciating treatment benefits while active but watching improvements gradually fade over months post-discontinuation, with timeline showing first 2 months maintaining most benefits creating initial optimism, months 2-4 showing noticeable decline returning toward baseline, months 4-8 continuing regression approaching pre-treatment status, and stabilization occurring 60-80% back toward original baseline with only modest long-term improvement retention

Centrally, particularly within the brainstem, this reduction in sympathetic outflow leads to decreased peripheral vascular resistance and a consequent reduction in arterial blood pressure ( panel 6 )

Prevalence and trends in obesity among US adults, 1999-2000