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Direct electron transfer from the low-potential carriers to dioxygen would not only generate heat rather than conserving energy but would also generate reactive dioxygen species deleterious to the cell

& Iannacone, M

10.1001/jamainternmed.2023.1838 92

In addition, changes in drug uptake mechanisms, increased DNA repair capabilities, and alterations in apoptotic pathways can further contribute to multidrug resistance (MDR) (Vijayakumar et al., 2024[132])