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Fourth, MR requires stringent assumptions, i.e., the genetic variants are associated with the exposure, no confounders of the associations of the genetic variants with the outcomes exist, and the genetic variants are not associated with the outcomes other than via affecting the relevant exposure (no pleiotropy) [17]

On the cardiovascular system, melatonin regulates blood pressure circadian rhythms, exhibits an antagonistic action to angiotensin II (Ag II) [194, 195], and diminishes the flactuation of cerebral blood flow [196]

Age and ovarian reserve: Advanced maternal age raises the chance of chromosomal errors and miscarriage

In the next section, we will discuss the relationship and importance between the GSH system and ferroptosis in myocardial injury