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*Correspondence: Majda Hadziahmetovic, [email protected] Malek, [email protected] This article was submitted to Cellular Biochemistry, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Abbreviations AIH: Autoimmune hepatitis AILI: APAP-induced liver injury ALF: Acute liver failure ALT: Alanine aminotransferase APAP: Acetaminophen AST: Aspartate aminotransferase BCAAs: Branched-chain amino acids BCATs: Branched chain amino transferases CYP1A2: Cytochrome p450 1A2 CYP2E1: Cytochrome p450 2E1 FBS: Fetal bovine serum FPKM: Fragments Per Kilobase Per Million bases GMHI: Gut microbiome health index GSH: Glutathione GSSG: Oxidative glutathione HC: Healthy control LEfSe: Linear discriminant analysis effect size N2--GluGln: N2-gamma-Glutamylglutamine NAPQI: N-acetyl-p-benzoquinone imine PBS: Phosphate-buffered saline PCoA: Principal coordinate analysis PICRUSt2: Phylogenetic Investigation of Communities by Reconstruction of Unobserved States PLS-DA: Partial Least Squares Discriminant Analysis QC: Quality control RDA: Redundancy analysis SEM: Standard error of the mean YAP: Yes-associated protein References Ghany MG, Watkins PB

Scatter plot depicting the enrichment of metabolite sets associated with various metabolic and drug action pathways, as per the KEGG database