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10.1161/ATVBAHA.115.306670 Arterioscler

Deficiencies in catecholamines such as NE and DA [75, 79, 80] or dysregulation of such NTs, which are essential for normal brain function, including executive and attentional functions [33], are among the causing physiological alterations that have been reported to explain ADHD development

Loss of E-cadherin, the essential component of cell-to-cell conjugation, is considered a fundamental event in the EMT process [234, 235]

Clinical deficiency signs include cheilosis, glossitis, and dermatitis , although subclinical deficiency may disrupt metabolic pathways before symptoms appear