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E.StreltsovV.McCollG.et al (2017)

48, 519525 10.1016/j.freeradbiomed.2009.11.021 [DOI] [PMC free article] [PubMed] [Google Scholar] Joiner K

Propylthiouracil therapy: Switching from methimazole to PTU may be an option later for ongoing Graves management, but PTU can also cause agranulocytosis

For example, the TME has a lower pH (ranging from 6.5 to 7.2) compared to that of normal tissues (with a pH around 7.4) owing to the Warburg effect (Liberti and Locasale, 2016), and it is hypoxic due to the insufficient blood supply to tumor tissue and the increased oxygen consumption by cancer cells (Chen Z