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In obese mice, combining ERR activation with dietary control yields additive improvements in fat mass and hepatic features, suggesting compatibility with lifestyle or other pharmacological interventions

53 , e12854 (2020)

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Taken together, these flux adjustments propose a reprogrammed metabolism in which central-carbon and amino-acid reactions are repurposed to prioritize antioxidant defense rather than biosynthetic throughput required for high-level IgG production