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Mol Endocrinol 24:886897 Michael SL, Pumford NR, Mayeux PR, Niesman MR, Hinson JA (1999) Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species

Indeed, a large number of enzymes (xanthine oxidase, nitric oxide synthetase, p450 cytochromes) and organelles (mitochondria, peroxisomes) produce ROS as a metabolic byproduct

2 Trace minerals including Zn, Se, Cu, and Mn are involved in several reproductive functions including granulosa cell proliferation and steroidogenesis, 47 corpus luteum (CL) function, 48 oocyte quality, 49-52 embryo development 51,53 and implantation, production of interferon tau, fetal development and organogenesis, 54 placentation, oxygen transportation, parturition, and uterine involution (Figure 3)

J Nutr Metab 2018:7195760