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This minimizes the risk to the main vial, but introduces its own set of challenges regarding the stability of the solution in a plastic syringe and the increased risk of contamination

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Formulations outside these ranges are either underdosed (ineffective) or overdosed (wasteful and potentially hepatotoxic at methionine levels above 100 mg per injection)

2.2.4 Roles of defensins in abiotic stresses 2.2.4.1 Defensin-mediated mechanisms for heavy metal tolerance A primary mechanism for heavy metal tolerance is the chelation of metal ions by the cysteine-rich domains of defensins, followed by the efflux of the metal-defensin complex from the cytoplasm to less sensitive extracellular compartments like cell walls or the apoplast, or into vascular tissues for transport (Luo et al., 2018