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Myocardial lipid accumulation and lipotoxicity in heart failure

PEF is considered a gentle, sub-lethal membrane permeabilisation technology, which relies on the exposure of the plant material to an external electrical field, in the form of short repetitive high voltage pulses, at a sufficient level induces the transient or permanent formation of pores in cell membranes 11

The TPP-conjugated photosensitizer chloramphenicol e6 (Ce6) selectively accumulates in mitochondria, colocalizes with 88% of mitochondria, and has potent cytotoxic activity, thereby significantly enhancing PDT efficacy (121, 122)

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