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Specific brain regions and circuits, such as the orbital frontal cortex and anterior cingulate cortex, can be correlated with NPS-like manifestations

Glutamate Kindling An imbalance between GABA and glutamate can also result in a phenomenon called kindling, defined in neurology as : a process in which repeated stimuli sensitize the brain to react when the stimulus is re-applied

The mechanisms of action of Pycnogenol were explored in several in vitro , in vivo and in clinical studies over the years ( at the molecular level

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