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SOD1 G93A GPX4 mice also showed delayed disease onset and increased motor function, which were correlated with ameliorated spinal motor neuron degeneration and reduced lipid peroxidation

Therefore, due to their widespread distribution in fruits, cereals, legumes, and vegetables, and ultimately in all plant-based food, polyphenols are the ideal candidate to help the general population cope with oxidative stress situations: by adhering to the recommended guidelines, for 5 portions of fruit and vegetables per day, polyphenols intake ingested could contribute to the individual's health protection [49]

A study in human GBMs showed that NETs promote IL-8 secretion in GBMs by stimulating the NF-B signalling pathway, which in turn stimulates endothelial cells to generate blood vessels to deliver essential nutrients and oxygen to the tumour site (205)

Short and hydrophobic groups such as the acetyl moiety fit optimally into the narrow pocket, supporting highly efficient catalysis