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The acetylation process of INH varies genetically and is generally categorized as either slow or rapid, with slow acetylators showing a relative deficiency in N-acetyltransferase

Periyasamy-Thandavan et al

Thus and simple bromelain delivery may require high doses of the active principle also due to the characteristics of the extracellular matrix (ECM) which constitutes a barrier that slows down or prevents the spread of drugs in the parenchyma of the tumor