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Ammonia readily crosses the blood-brain barrier and is thought to inhibit glutamate uptake, thereby increasing extracellular glutamate concentrations in the brain and resulting in activation of NMDA receptors

Changes in the ileal SCFAs profile were found as well, being remarkable the trend toward significant increments in the molar proportions of butyrate in the CARN group, probably explained by microbiome changes at this location

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Regardless of whether they were followed up for 5 years or 10 years for OS, the SLNB group was found to be non-inferior to the ALND group in both follow-up periods