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73,74,75 While suppression of the immune response is necessary to limit tissue damage during inflammation, in certain diseases, such as sepsis and cancer, it can lead to a breakdown of the immune defense system

therefore, the choice and dosage of probiotics should be proportional to induce balance and eubiosis of gut microbiota ( Probiotics reinforce the intestinal barrier by stimulating mucus secretion, maintaining tight junction integrity, and inhibiting lipopolysaccharide translocation

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The classical mechanism consists of liganded GR homodimerization and binding to conserved palindromic DNA sequences known as glucocorticoid response elements (GRE), leading to gene transactivation