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Concurrently, the compromised intestinal barrier facilitates the translocation of microbial components, including LPS and flagellar proteins, along with secondary bile acids, into the systemic circulation, thereby triggering systemic inflammatory responses (103)

Overall, the application of COMT inhibitors requires balancing the clinical benefit of extended "on" time against the risk of exacerbating dyskinesia

Both macroautophagy and CMA are reported to have compensatory functions