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Preladenant, a selective A(2A) receptor antagonist, is active in primate models of movement disorders

Crucially, this study shifted the scientific paradigm from a simple model of "glutathione depletion" to a model of an "overwhelmed compensatory mechanism." The discovery that circulating immune cells in these patients actually have elevated glutathione levelswhile simultaneously suffering from a severe depletion of other protective enzymes like SOD2revealed that the cells are desperately, and unsuccessfully, trying to fight off a catastrophic level of oxidative damage

[21] and Sillapachaiyaporn et al

In two-week-old adults of Ap