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ex DC., exhibits well-documented anti-inflammatory activity ( PUN, a major polyphenol found in the peel of Punica granatum L., exhibits antioxidant and anti-inflammatory properties ( Collectively, these studies implicate autophagy-linked signaling pathways involving PI3K/AKT/mTOR, ULK1/Beclin-1/VPS34, p62/Nrf2, and AMPK/mTOR/ULK1 as a convergent axis through which linarin, Lico A, and PUN ameliorate the phenotypes of MAFLD ( 7 Perspectives and conclusion The prevalence of MAFLD is increasing worldwide, driven by an interconnected pathogenic network that includes IR, lipotoxicity, oxidative stress, mitochondrial and ER stress, chronic low-grade inflammation, and gutliver axis dysfunction

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In this article, we focus on the latter, because this feature is objectively and consistently identified in ME/CFS patients (for details, see section Abnormal CBF) (van Campen et al., 2020)