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Realistically, fundamental issues that stand in the way of large-scale drug production include the vast number of biological GST family members, with each subtype having their own structural and functional differences, in addition to the existence of several genetic modifiers

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The approach combines hypotonicity and thermosensitive gel-forming polymers (e.g., Pluronic F127) formulated below their critical gel concentration (CGC), allowing for rapid and uniform water absorption-driven spreading over the ocular surface