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In a multicenter, randomized, doubleblind, placebocontrolled phase 2 study (ClinicalTrails.gov Identifier: NCT01119833), Rivipansel showed clinical and meaningful reductions in multiple measures of VOC compared with those receiving standard of care treatment (Telen et al., 2015)

This could reduce the protection that these proteins provide to dopaminergic neurons, increasing their vulnerability to oxidative stress damage (129, 220)

Their biologic activity is supported by decades of foundational cellular medicine research and growing clinical interest

This property helps in reducing microbial load and subsequent inflammation