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Reply to: DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition

Does severity of spinal cord injury predict likelihood of suffering chronically from severe depression and anxiety

In contrast, probiotic intervention antagonizes ferroptosis through mechanisms such as reducing inflammation, repairing intestinal barrier, releasing antimicrobial peptides (cAMPs), regulating iron overload, and inhibiting lipid peroxidation (182, 183), thereby ameliorating the pathological phenotype of IBD ( Figure 3 )

Further validation with additional classes of chemicals is needed to generate confidence that information will be applicable to human disease