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In sum, animal studies suggest that ghrelin may exert antidepressant effects via neuroprotection in the hippocampus, and obesity-related reductions in ghrelin levels 42,43 could partly explain the higher susceptibility to depressive symptoms in individuals with obesity

As monotherapy , a multicentre, randomised, double-blind, placebo-controlled and active-controlled Phase 2 dose-finding trial enrolled 706 adults with overweight or obesity (without diabetes) to once-weekly subcutaneous cagrilintide across doses of 0.3 to 4.5 mg over 26 weeks

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