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Nature Route of administration is not merely a convenience issue

10.1016/j.biopha.2019.109443 215 WangX.YuJ.-y.SunY.WangH.ShanH.WangS

This pathway regulates: Protein synthesis (through mTORC1 activation) Cell survival and proliferation (Akt-dependent) Glucose metabolism Mitochondrial function MAPK/ERK Pathway Activation IGF-1 LR3 also activates the mitogen-activated protein kinase (MAPK/ERK) pathway, which regulates gene transcription and cell proliferation independent of mTOR signalling